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4-Fluoro-α-(2-methyl-1-0xo-propyl)-y-oxo-N-β-diphenyl benzene butanamide(M4)

  • CasNo:125971-96-2

Product Description

4-Fluoro-α-(2-methyl-1-0xo-propyl)-y-oxo-N-β-diphenyl benzene butanamide(M4) Good Manufacturer supply High Quality 125971-96-2

  • Molecular Formula: C26H24FNO3
  • Molecular Weight: 417.48
  • Appearance/Colour: white to off-white solid 
  • Vapor Pressure: 0mmHg at 25°C 
  • Melting Point: 196-198 °C 
  • Refractive Index: 1.599 
  • Boiling Point: 631.4 °C at 760 mmHg 
  • PKA: 11.52±0.59(Predicted) 
  • Flash Point: 335.6 °C 
  • PSA： 63.24000 
  • Density: 1.212 g/cm3 
  • LogP: 5.34520 

2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide(Cas 125971-96-2) Usage

InChI:InChI=1/C26H24FNO3/c1-17(2)24(29)23(26(31)28-21-11-7-4-8-12-21)22(18-9-5-3-6-10-18)25(30)19-13-15-20(27)16-14-19/h3-17,22-23H,1-2H3,(H,28,31)

125971-96-2 Relevant articles

[18F]Atorvastatin: synthesis of a potential molecular imaging tool for the assessment of statin-related mechanisms of action

Antunes, Inês F.,Clemente, Gon?alo S.,D?mling, Alexander,Elsinga, Philip H.,Rickmeier, Jens,Ritter, Tobias,Zarganes-Tzitzikas, Tryfon

, (2020/04/24)

Background: Statins are lipid-lowering a...

Method for synthesizing atorvastatin calcium intermediate by multi-component one-pot method

-

Paragraph 0152-0179, (2020/11/23)

The invention provides a method for synt...

Atorvastatin key intermediate for preparing environmental protection

-

Paragraph 0051-0054; 0057-0058, (2019/07/01)

The present invention provides a kind of...

Preparation method of atorvastatin calcium

-

, (2018/07/30)

The invention belongs to the technical f...

125971-96-2 Process route

4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

4-methyl-3-oxo-N-phenyl-2-(phenylmethylene)pentanamide
125971-57-5

4-methyl-3-oxo-N-phenyl-2-(phenylmethylene)pentanamide

1,2-bis(4-fluorophenyl)-2-hydroxyethan-1-one
53458-16-5

1,2-bis(4-fluorophenyl)-2-hydroxyethan-1-one

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2,125971-58-6

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

Conditions
Conditions Yield
With triethylamine; ethyl thiazolium catalyst; Yield given. Multistep reaction; or with methyl thiazolium catalyst; 1) EtOH;
2-bromo-1-(4-fluorophenyl)-2-phenylethan-1-one
88675-31-4

2-bromo-1-(4-fluorophenyl)-2-phenylethan-1-one

4-methyl-3-oxo-N-phenylpentanamide
124401-38-3

4-methyl-3-oxo-N-phenylpentanamide

1-(4-fluorophenyl)-2-phenylethanone
347-84-2

1-(4-fluorophenyl)-2-phenylethanone

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide
125971-96-2,125971-58-6

2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid phenylamide

Conditions
Conditions Yield
With potassium carbonate; In acetone; at 20 ℃; for 5h; Reagent/catalyst; Time; Darkness;
80%

125971-96-2 Upstream products

  • 459-57-4
    459-57-4

    4-fluorobenzaldehyde

  • 125971-57-5
    125971-57-5

    4-methyl-3-oxo-N-phenyl-2-(phenylmethylene)pentanamide

  • 222320-29-8
    222320-29-8

    4-Methyl-3-oxo-N-phenyl-2(phenylmethylene)pentanamide

  • 124401-38-3
    124401-38-3

    4-methyl-3-oxo-N-phenylpentanamide

125971-96-2 Downstream products

  • 125971-95-1
    125971-95-1

    tert-butyl (4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate

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