3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2.4]triazolo[4,3-a]pyrazine hydrochloride
- CasNo:762240-92-6
Product Description
Export Top Purity 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2.4]triazolo[4,3-a]pyrazine hydrochloride 762240-92-6 In Stock
- Molecular Formula: C6H7F3N4.HCl
- Molecular Weight: 228.605
- Appearance/Colour: white solid
- Melting Point: 236-246oC
- Boiling Point: 266.2 °C at 760 mmHg
- Flash Point: 114.8 °C
- PSA： 42.74000
- LogP: 1.53090
762240-92-6 Relevant articles
Preparation method of sitagliptin intermediate
-
Paragraph 0024; 0030; 0034-0035; 0039-0040; 0044-0045; 0049, (2021/02/13)
The invention relates to a preparation m...
Green synthesis method of sitagliptin intermediate
-
Paragraph 0032; 0044-0047; 0051-0052; 0056-0059, (2021/10/27)
The invention relates to a green synthes...
Preparation method of sitagliptin intermediate
-
Paragraph 0074-0076, (2021/06/22)
The invention discloses a preparation me...
Preparation method of sitagliptin intermediate
-
Paragraph 0036, (2020/07/15)
The invention provides a method for prep...
762240-92-6 Process route
-
![2,2,2-trifluoro-N’-[(2Z)-piperazin-2-ylidene]acetohydrazide](/upload/2026/4/8c109ce3c0de46ec999c7fb88af57094_61abdb92-95b8-4cd6-b385-bd46ca8d816f.png)
-
763105-70-0
2,2,2-trifluoro-N’-[(2Z)-piperazin-2-ylidene]acetohydrazide
-
![3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride](/upload/2026/4/0eaadd5ac6a64a32912275683d6c8dde_a5f03604-9ddb-4ff7-87f2-c57c02dc54ac.png)
-
762240-92-6
3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride;
In
methanol;
at 55 ℃;
for 0.5h;
|
92%
|
|
With
hydrogenchloride;
In
ethanol; water;
at 50 - 54 ℃;
for 3.5h;
Temperature;
|
92.6%
|
|
With
hydrogenchloride;
In
isopropyl alcohol;
at 60 - 65 ℃;
for 2h;
Temperature;
Inert atmosphere;
Large scale;
|
91%
|
|
With
hydrogenchloride;
In
methanol;
at 55 ℃;
|
90.7%
|
|
2,2,2-trifluoro-N’-[(2Z)-piperazin-2-ylidene]acetohydrazide;
In
ethyl acetate;
at 60 ℃;
for 0.333333h;
Inert atmosphere;
With
hydrogenchloride;
In
ethyl acetate;
for 3h;
Inert atmosphere;
|
90.1%
|
|
With
hydrogenchloride;
In
methanol; tert-butyl methyl ether;
at 20 ℃;
for 1.66667 - 2.5h;
|
|
|
With
hydrogenchloride;
In
methanol;
at 55 ℃;
for 0.75h;
|
|
|
With
hydrogenchloride;
In
methanol; water;
at 20 - 55 ℃;
for 0.916667 - 1.75h;
|
|
|
With
hydrogenchloride;
In
methanol; water;
at 55 ℃;
for 0.75h;
|
|
|
With
hydrogenchloride;
In
methanol;
at 55 ℃;
for 0.75h;
|
|
|
With
hydrogenchloride;
In
methanol; water;
at 55 ℃;
for 0.75h;
|
|
|
With
hydrogenchloride;
In
methanol; water;
at 55 ℃;
for 0.75h;
|
|
|
2,2,2-trifluoro-N’-[(2Z)-piperazin-2-ylidene]acetohydrazide;
With
hydrogenchloride;
In
methanol;
at 55 ℃;
for 0.75h;
2,2,2-trifluoro-N’-[(2Z)-piperazin-2-ylidene]acetohydrazide;
With
hydrogenchloride;
In
methanol; tert-butyl methyl ether;
at 20 ℃;
for 1h;
|
|
|
2,2,2-trifluoro-N’-[(2Z)-piperazin-2-ylidene]acetohydrazide;
With
hydrogenchloride;
In
methanol;
at 55 ℃;
for 0.75h;
In
tert-butyl methyl ether;
at 20 ℃;
for 1h;
|
|
|
With
hydrogenchloride;
In
methanol; water;
at 20 - 55 ℃;
for 0.916667 - 1.75h;
|
|
|
With
hydrogenchloride;
In
methanol; water;
at 55 ℃;
for 0.75h;
|
|
|
With
hydrogenchloride;
In
methanol; water;
at 20 - 55 ℃;
for 0.916667 - 1.75h;
|
|
|
With
hydrogenchloride;
In
methanol;
at 50 - 55 ℃;
for 3h;
|
|
|
With
hydrogenchloride;
In
methanol; water;
at 55 ℃;
for 0.75h;
|
|
|
With
hydrogenchloride;
In
methanol; water;
at 55 ℃;
for 0.75h;
|
|
|
With
hydrogenchloride;
In
methanol; water;
at 55 ℃;
for 0.75h;
|
|
|
With
hydrogenchloride;
In
methanol; water;
at 55 ℃;
for 0.75h;
|
|
|
With
hydrogenchloride;
In
methanol;
at 55 ℃;
for 1h;
|
1.36 g
|
-
![3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine](/upload/2026/4/3c301b9de7d545b895ac4c9c6d52af74_8825cd41-362a-4031-ae7b-c0479284837d.png)
-
486460-20-2
3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine
-
-
762240-92-6
3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
| Conditions | Yield |
|---|---|
|
3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine;
With
palladium on activated carbon; hydrogen;
In
methanol;
at 40 - 45 ℃;
for 24h;
under 2625.26 - 3375.34 Torr;
With
hydrogenchloride;
In
isopropyl alcohol;
at 0 - 5 ℃;
|
82.9%
|
|
Multi-step reaction
with
2
steps
1: palladium 10% on activated carbon; hydrogen / ethanol / 45 °C / 3345.86 Torr / Large scale
2: hydrogenchloride / Isopropyl acetate / 1 h / 20 °C / Large scale
With
hydrogenchloride; palladium 10% on activated carbon; hydrogen;
In
ethanol; Isopropyl acetate;
|
|
|
With
palladium 10% on activated carbon; hydrogen;
In
Isopropyl acetate;
at 40 - 45 ℃;
under 2585.81 Torr;
|
8 g
|
762240-92-6 Upstream products
-
763105-70-0
2,2,2-trifluoro-N’-[(2Z)-piperazin-2-ylidene]acetohydrazide
-
823817-55-6
(S)-Sitagliptin
-
486460-20-2
3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine
-
486460-21-3
3-trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
762240-92-6 Downstream products
-
764667-65-4
1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butane-1,3-dione
-
874360-10-8
tert-butyl [(1S,2R,5S)-5-[3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-2-(2,4,5-trifluorophenyl)cyclohexyl]carbamate
-
486460-23-5
(R)-tert-butyl 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate
-
959839-54-4
6-(4-Fluoro-3-{[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]carbonyl}benzyl)-4,5-dimethylpyridazin-3(2H)-one