Boc-(R)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid
- CasNo:486460-00-8
Product Description
Chinese Factory Supply Wholesale Boc-(R)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid 486460-00-8 with Cheap Price We provide high quality BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID (CAS 486460-00-8), at a very affordable prices to our customers.
1.What is the BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID ?
Boc-(R) -3-amino-4 -(2,4, 5-trifluorophenyl) butyric acid is an important intermediate for the preparation of sitagliptin. Sitagliptinphosphate is the first dipeptidase -IV(dpp-4) inhibitor approved by FDA in 2006. It is used for the treatment of type II diabetes mellitus. It has obvious hypoglycemic effect when used alone or in combination with metformin and pioglitazone, and it is safe to take, well tolerated, with few adverse reactions.
(R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic Acid has been used as a reactant for the preparation of dipeptidyl peptidase-4 (DPP4) inhibitors for the treatment of type 2 diabetes, such as sitagliptin.
2.What is the CAS number for BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID ?
The CAS number of BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID is 486460-00-8.
More information of BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID 486460-00-8 are:
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CAS?Number |
486460-00-8 |
|
Density |
1.292 g/cm3 |
|
Melting Point |
136-138℃ |
|
Boiling Point |
443.1 °C at 760 mmHg |
|
Flash Point |
221.8 °C |
|
Vapor Pressure |
1.25E-08mmHg at 25°C |
|
Refractive Index |
1.494 |
|
HS CODE |
2942000000 |
|
PSA |
75.63000 |
|
LogP |
3.40530 |
|
Pka |
4.30±0.10(Predicted) |
3.What is the molecular formula of BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID ?
The chemical formula of?BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID is C15H18F3NO4 which containing 15 Carbon atoms,18 Hydrogen atoms,3 Fluorine atoms,1 Nitrogen atoms and 4 Oxygen atoms,and the molecular weight, and the molecular weight of BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID is 333.307
4.What is BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID(486460-00-8)used for?
Boc-(R) -3-amino-4 -(2,4, 5-trifluorophenyl) butyric acid is an important intermediate for the preparation of sitagliptin. Sitagliptinphosphate is the first dipeptidase -IV(dpp-4) inhibitor approved by FDA in 2006. It is used for the treatment of type II diabetes mellitus. It has obvious hypoglycemic effect when used alone or in combination with metformin and pioglitazone, and it is safe to take, well tolerated, with few adverse reactions.
InChI:InChI=1/C15H18F3NO4/c1-15(2,3)23-14(22)19-9(6-13(20)21)4-8-5-11(17)12(18)7-10(8)16/h5,7,9H,4,6H2,1-3H3,(H,19,22)(H,20,21)/t9-/m1/s1
Relevant articles related to BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID:
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Article |
Source |
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Application of the asymmetric hydrogenation of enamines to the preparation of a beta-amino acid pharmacophore |
Kubryk, Michele,Hansen, Karl B. , p. 205 - 209 (2006) |
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Preparation method of 1-morpholinyl-4-(2,4,5-trifluorophenyl)butane-1,3-dione |
- Paragraph 0087-0088; 0091, (2020/05/02) |
5.Chinese Factory Supply Wholesale Boc-(R)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid 486460-00-8 with Cheap Price
Hangzhou World-wide Biology Tech Co.ltd is a quality supplier of BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID 486460-00-8.