(R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid
- CasNo:181289-33-8
Product Description
Quality Factory Supply 99% Pure (R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid 181289-33-8 with Efficient Delivery
- Molecular Formula: C9H17NO3
- Molecular Weight: 187.239
- Vapor Pressure: 0mmHg at 25°C
- Melting Point: 128-133 °C
- Refractive Index: 1.475
- Boiling Point: 401.929 °C at 760 mmHg
- PKA: 4.68±0.10(Predicted)
- Flash Point: 196.88 °C
- PSA： 80.39000
- Density: 1.081 g/cm3
- LogP: 1.69910
(R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid(Cas 181289-33-8) Usage
|
Sources |
https://quod.lib.umich.edu/a/ark/5550190.0011.a22?rgn=main;view=fulltext https://www.researchgate.net/publication/269660675_Synthesis_and_characterization_of_impurities_of_an_anticonvulsant_drug_Pregabalin |
InChI:InChI=1/C9H17NO3/c1-6(2)3-7(4-8(10)11)5-9(12)13/h6-7H,3-5H2,1-2H3,(H2,10,11)(H,12,13)/t7-/m1/s1
181289-33-8 Relevant articles
Synthesis and characterization of impurities of an anticonvulsant drug, Pregabalin
Sripathi, Somaiah,Somesetti, Narender Rao,Veeramalla, Raju,Challa, Nageswar Rao,Peddi, Srinivasa Rao,Karnati, Venugopal Reddy
, p. 266 - 275 (2010)
During the process development of Pregab...
Method for preparing pregabalin intermediate
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Paragraph 0023-0042, (2021/03/06)
The invention discloses a method for pre...
METHOD FOR PREPARING PREGABALIN INTERMEDIATE (R)-3-(CARBAMOYLMETHYL)-5-METHYLHEXANOIC ACID
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Paragraph 0039; 0041; 0043; 0045; 0047, (2021/04/23)
A method for preparing pregabalin chiral...
Development of a new synthesis approach for S-pregabalin by optimizing the preparation stages
Mansoori, Arsalan,Zahednezhad, Fahimeh,Bavili Tabrizi, Ahad,Shahbazi Mojarrad, Javid
, p. 89 - 101 (2019/09/13)
In the present study, we aimed to optimi...
AN IMPROVED PROCESS FOR THE PREPARATION OF PREGABALIN
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Page/Page column 15; 16; 18; 19, (2019/10/29)
The present invention relates to an impr...
181289-33-8 Process route
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-
(R)-methyl 3-(carbamoylmethyl)-5-methylhexanoate
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-
181289-33-8
(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid
| Conditions | Yield |
|---|---|
|
(R)-methyl 3-(carbamoylmethyl)-5-methylhexanoate;
With
hydrogenchloride;
In
water;
at 20 - 25 ℃;
for 1 - 10h;
With
sodium hydroxide;
In
water;
pH=3;
Product distribution / selectivity;
|
|
|
(R)-methyl 3-(carbamoylmethyl)-5-methylhexanoate;
With
hydrogenchloride; water;
at 20 - 25 ℃;
With
sodium hydroxide;
In
water;
pH=3;
|
-
-
181289-25-8
(3S)-3-(2-methoxy-2-oxoethyl)-5-methylhexanoic acid
-
-
181289-33-8
(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid
| Conditions | Yield |
|---|---|
|
(3S)-3-(2-methoxy-2-oxoethyl)-5-methylhexanoic acid;
With
ammonia;
In
water;
at 20 - 80 ℃;
for 6 - 92h;
under 760.051 - 1520.1 Torr;
With
hydrogenchloride;
In
water;
pH=1 - 3;
Product distribution / selectivity;
|
60%
|
|
(3S)-3-(2-methoxy-2-oxoethyl)-5-methylhexanoic acid;
With
ammonia; ammonium chloride;
In
water;
at 20 - 40 ℃;
for 42.5h;
With
hydrogenchloride;
In
water;
pH=4;
Product distribution / selectivity;
|
|
|
(3S)-3-(2-methoxy-2-oxoethyl)-5-methylhexanoic acid;
With
ammonia;
In
water; toluene;
at 20 ℃;
for 88h;
With
sulfuric acid;
In
water;
pH=3;
Product distribution / selectivity;
|
|
|
With
ammonium hydroxide;
at 25 - 90 ℃;
for 75h;
Reagent/catalyst;
Temperature;
|
75 g
|
181289-33-8 Upstream products
-
181289-25-8
(3S)-3-(2-methoxy-2-oxoethyl)-5-methylhexanoic acid
-
67-56-1
methanol
-
185815-59-2
3-isobutylglutaric anhydride
-
1001296-65-6
(R)-(-)-phenylglycinol salt of (R)-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid
181289-33-8 Downstream products
-
1237492-12-4
C15 H20 N2 O5
-
75143-89-4
5-methyl-3-carboxymethylhexanoic acid
-
148553-50-8
pregabilin
-
61312-87-6
4-(2-methylpropyl)pyrrolidin-2-one