N-I[2-I[14-[[[(Hexyloxy)carbonyl]aMidino]iMinoMethyl]phenyl]aMino]Methyl]-1-Methyl-1H-benziMidazol-5- yl]carbonyj-N-2-pyridyl-beta-alanine,ethyl ester (DG13)
- CasNo:211915-06-9
Product Description
Quality products?make an important contribution to long-term revenue and profitability. Quality Factory Sells Top Purity 99% N-I[2-I[14-[[[(Hexyloxy)carbonyl]aMidino]iMinoMethyl]phenyl]aMino]Methyl]-1-Methyl-1H-benziMidazol-5- yl]carbonyj-N-2-pyridyl-beta-alanine,ethyl ester (DG13) 211915-06-9 with Safe Delivery
1.What is the Dabigatran etexilate ?
Dabigatran Etexilate is an oral anticoagulant and direct thrombin inhibitor.
-
-
6092-54-2
n-hexyl chloroformate
-
-
3-({2-[(4-carbamimidoyl-phenylamino)methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}pyridin-2-yl-amino)-propionic acid ethyl ester dihydrochloride
-
-
211915-06-9
dabigatran etexilate
| Conditions | Yield |
|---|---|
|
3-({2-[(4-carbamimidoyl-phenylamino)methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}pyridin-2-yl-amino)-propionic acid ethyl ester dihydrochloride;
With
potassium carbonate;
In
tetrahydrofuran; water;
at 20 ℃;
for 0.333333h;
n-hexyl chloroformate;
In
tetrahydrofuran; water;
at 20 ℃;
for 5h;
|
63.3% |
|
With
potassium carbonate;
In
tetrahydrofuran; water;
|
-
-
6092-54-2
n-hexyl chloroformate
-
-
3-({2-[(4-carbamimidoyl-phenylamino)methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}pyridin-2-ylamino)propionic acid ethyl ester hydrochloride
-
-
211915-06-9
dabigatran etexilate
| Conditions | Yield |
|---|---|
|
3-({2-[(4-carbamimidoyl-phenylamino)methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}pyridin-2-ylamino)propionic acid ethyl ester hydrochloride;
With
potassium carbonate;
In
tetrahydrofuran;
at 20 ℃;
for 0.25h;
n-hexyl chloroformate;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
Further stages.;
|
51% |
|
With
potassium carbonate;
In
tetrahydrofuran; water;
at 20 ℃;
for 2h;
|
2.What is the CAS number for Dabigatran etexilate ?
The CAS number of Dabigatran etexilate is 211915-06-9.
More information of Dabigatran etexilate 211915-06-9 are:
|
CAS?Number |
211915-06-9 |
|
Density |
1.24 g/cm3 |
|
Melting Point |
128-129° |
|
Boiling Point |
827.9 °C at 760 mmHg |
|
Flash Point |
454.5 °C |
|
Vapor Pressure |
1.49E-27mmHg at 25°C |
|
Refractive Index |
1.614 |
|
HS CODE |
2933990090 |
|
PSA |
154.03000 |
|
LogP |
6.37590 |
|
Pka |
9.88±0.46(Predicted) |
3.What are another words for Dabigatran etexilate ?
Synonyms?for?Dabigatran etexilate 211915-06-9:Ethyl 3-(((2-(((4-((((hexyloxy)carbonyl)amino)iminomethyl)phenyl)amino)methyl)-1-methyl-1H-benzimidazol-5-yl)carbonyl)(pyridin-2-yl)amino)propanoate;
4.What is the molecular formula of Dabigatran etexilate?
The chemical formula of ?Dabigatran etexilate is?C34H41N7O5 which containing 34 Carbon atoms,41 Hydrogen atoms,7 Nitrogen atoms and 5 Oxygen atoms,and the molecular weight of??Dabigatran etexilate?is 627.743.
5.What is Dabigatran etexilate (211915-06-9) used for?
Dabigatran etexilate is an orally administered pro-drug of dabigatran, which is a direct inhibitor of thrombin and a potent anticoagulant. The serine protease thrombin is the final mediator in the coagulation cascade that leads to the production of fibrin, the main protein component of blood clots. Thrombin is also a potent activator of platelets. Consequently, thrombin inhibitors have found utility as anticoagulants in treating arterial and venous thrombosis. Warfarin, although orally available, has a narrow therapeutic index and requires frequent monitoring and dosage adjustment. Low-molecular-weight heparins provide better safety profile and less inter-patient variability; however, these agents are only available for parenteral administration. Direct thrombin inhibitors (DTIs) are a new class of anticoagulants that act by directly binding to thrombin at its catalytic or fibrinogen-binding sites, or both. Unlike the heparins, DTIs do not require the activation of secondary factors such as antithrombin to derive their activity, which makes their action more predictable. In addition, their ability to inhibit both free and clot-bound thrombin predisposes them for enhanced anticoagulation effect.
InChI:InChI=1/C34H41N7O5/c1-4-6-7-10-21-46-34(44)39-32(35)24-12-15-26(16-13-24)37-23-30-38-27-22-25(14-17-28(27)40(30)3)33(43)41(20-18-31(42)45-5-2)29-11-8-9-19-36-29/h8-9,11-17,19,22,37H,4-7,10,18,20-21,23H2,1-3H3,(H2,35,39,44)
Relevant articles related to Dabigatran etexilate:
|
Article |
Source |
|
An improved process for preparation of dabigatran etexilate mesylate |
Sharif, Sd. Khasim,Ramudu, B. Sri,Nunna, Rambabu,Ramachandran , p. 1253 - 1257 (2017) |
|
Benzenesulfonate and preparation method thereof, and application of benzenesulfonate in preparation of dabigatran etexilate |
- Paragraph 0077-0081, (2020/07/02) |
6.Buy Dabigatran etexilate with the best price .
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