2-([(5S)-2-0xo-3-[4-(3-0xomorpholin-4-yl)phenyl]-1,3-0xazolidin-5-y]methyl)-1H-isoindole-1,3(2H)-dione
- CasNo:446292-08-6
Product Description
Manufacturer supply high quality 2-([(5S)-2-0xo-3-[4-(3-0xomorpholin-4-yl)phenyl]-1,3-0xazolidin-5-y]methyl)-1H-isoindole-1,3(2H)-dione 446292-08-6 with GMP standards
- Molecular Formula: C22H19N3O6
- Molecular Weight: 421.409
- Appearance/Colour: White solid
- Vapor Pressure: 0mmHg at 25°C
- Melting Point: 250
- Refractive Index: 1.658
- Boiling Point: 702.933 °C at 760 mmHg
- PKA: 0.99±0.20(Predicted)
- Flash Point: 378.92 °C
- PSA： 96.46000
- Density: 1.466 g/cm3
- LogP: 1.73910
1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]-(Cas 446292-08-6) Usage
|
Flammability and Explosibility |
Nonflammable |
InChI:InChI=1/C22H19N3O6/c26-19-13-30-10-9-23(19)14-5-7-15(8-6-14)24-11-16(31-22(24)29)12-25-20(27)17-3-1-2-4-18(17)21(25)28/h1-8,16H,9-13H2/t16-/m1/s1
446292-08-6 Relevant articles
Preparation method of rivaroxaban intermediate
-
, (2020/05/02)
The invention provides a preparation met...
Oxazolidinone derivative and preparation method thereof
-
Paragraph 0018-0019, (2020/03/05)
The invention relates to a preparation m...
Preparation method of rivaroxaban intermediate
-
Paragraph 0025; 0026, (2020/04/17)
The invention belongs to the field of dr...
Preparation method and use of rivaroxaban intermediate
-
Paragraph 0028; 0029, (2019/04/26)
The present invention relates to a prepa...
446292-08-6 Process route
-
-
1325210-64-7
4-(4-isocyanatophenyl)morpholin-3-one
-
-
161596-47-0
(S)-N-glycidylphthalimide
-
![2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione](/upload/2026/4/41465a4ce3054fe798cf67ffdfe98e0e_a53977f5-de22-4190-a40b-07e183b9cd26.png)
-
446292-08-6,1424944-35-3
2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione
| Conditions | Yield |
|---|---|
|
With
3-methyl-1-butyl acetate; magnesium chloride;
at 120 ℃;
for 4h;
Solvent;
Reagent/catalyst;
Temperature;
|
95.5%
|
|
With
lithium iodide;
In
chlorobenzene;
at 115 ℃;
for 4h;
Reagent/catalyst;
Solvent;
Temperature;
|
94.09%
|
-
-
634905-12-7
4-(4-bromophenyl)morpholin-3-one
-
![(S)-2-[[2-oxo-1,3-oxazolidin-5-yl]methyl]-1H-isoindole-1,3(2H)-dione](/upload/2026/4/3cb974720ffc4a96ad5b5317a83380b8_eb887058-e8d8-4d12-871e-1c73590d429f.png)
-
(S)-2-[[2-oxo-1,3-oxazolidin-5-yl]methyl]-1H-isoindole-1,3(2H)-dione
-
-
446292-08-6,1424944-35-3
2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione
| Conditions | Yield |
|---|---|
|
With
copper(l) iodide; N,N-dimethyl-ethanamine; potassium carbonate;
In
dichloromethane;
at 100 ℃;
for 15h;
Solvent;
Reagent/catalyst;
Sealed tube;
|
92.2%
|
|
With
copper(l) iodide; N,N-dimethyl-ethanamine; potassium carbonate;
In
dichloromethane;
at 100 ℃;
for 15h;
Sealed tube;
|
92.5%
|
446292-08-6 Upstream products
-
446292-07-5
2-((2S)-2-hydroxy-3-{[4-(3-oxomorpholin-4-yl)phenyl]amino}propyl)-1H-isoindole-1,3(2H)-dione
-
530-62-1
1,1'-carbonyldiimidazole
-
161596-47-0
(S)-N-glycidylphthalimide
-
438056-69-0
4-(4-aminophenyl)morpholin-3-one
446292-08-6 Downstream products
-
366789-02-8
Rivaroxaban
-
1430407-74-1
4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholin-3-one malonate