(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3- ylmethyl ester
- CasNo:149809-43-8
Product Description
Cost-effective and customizable (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3- ylmethyl ester 149809-43-8 in stock
- Molecular Formula: C21H21F2N3O4S
- Molecular Weight: 449.478
- Vapor Pressure: 9.85E-15mmHg at 25°C
- Melting Point: 100-102°C
- Refractive Index: 1.615
- Boiling Point: 608.1 °C at 760 mmHg
- PKA: 2.75±0.10(Predicted)
- Flash Point: 321.6 °C
- PSA： 91.69000
- Density: 1.40 g/cm3
- LogP: 4.28300
(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester(Cas 149809-43-8) Usage
InChI:InChI=1/C21H21F2N3O4S/c1-15-2-5-18(6-3-15)31(27,28)30-11-16-9-21(29-10-16,12-26-14-24-13-25-26)19-7-4-17(22)8-20(19)23/h2-8,13-14,16H,9-12H2,1H3/t16-,21-/m0/s1
149809-43-8 Relevant articles
Preparation method of posaconazole intermediate
-
, (2021/11/21)
The invention relates to the technical f...
POSACONAZOLE, COMPOSITION, INTERMEDIATE, PREPARATION METHOD THEREFOR, AND USES THEREOF
-
Paragraph 0246-0247, (2019/03/14)
The present invention relates to a compo...
Preparation method for preparing posaconazole midbody
-
, (2017/08/27)
The invention provides a method for prep...
IMPROVED PROCESS FOR THE PREPARATION OF ((3S,5R)-5-((1H-1,2,4-TRIAZOL-1-YL)METHYL)-5-(2,4-DIFLUOROPHENYL)TETRAHYDROFURAN-3-YL)METHYL-4-METHYLBENZENESULFONATE
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Page/Page column 22, (2015/05/06)
The present invention relates to process...
149809-43-8 Process route
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C14 H15 F2 N3 O2 *(x)ClH
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-
98-59-9
p-toluenesulfonyl chloride
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![(2R-cis)-2-(2,4-difluorophenyl)-4-[[(4-methylphenyl)sulfonyloxy]methyl]-2-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran](/upload/2026/4/3e6452d1e5124ee280e1951e40a62211_f2d32a3c-efdc-4380-9152-e55aa4529ff5.png)
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149809-43-8
(2R-cis)-2-(2,4-difluorophenyl)-4-[[(4-methylphenyl)sulfonyloxy]methyl]-2-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran
| Conditions | Yield |
|---|---|
|
C14H15F2N3O2*(x)ClH;
With
triethylamine;
In
dichloromethane;
at 12 - 22 ℃;
for 1h;
p-toluenesulfonyl chloride;
With
dmap;
In
dichloromethane;
at 12 - 25 ℃;
for 4h;
|
94%
|
-
-
1350466-82-8
C14 H15 F2 N3 O2 *ClH
-
-
98-59-9
p-toluenesulfonyl chloride
-
-
149809-43-8
(2R-cis)-2-(2,4-difluorophenyl)-4-[[(4-methylphenyl)sulfonyloxy]methyl]-2-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran
| Conditions | Yield |
|---|---|
|
With
dmap; triethylamine;
In
dichloromethane;
at 14 - 30 ℃;
|
94%
|
149809-43-8 Upstream products
-
98-59-9
p-toluenesulfonyl chloride
-
160709-02-4
((3R,5R)-5-((1H-1,2,4-triazole-1-yl) methyl)-5-(2,4-difluorophenyl) tetrahydrofuran-3-yl)methanol
-
182009-37-6
4-(2,4-Difluoro-phenyl)-pent-4-enoyl chloride
-
182210-71-5
((3R,5R)-5-(2,4-difluorophenyl)-5-(iodomethyl)tetrahydrofuran-3-yl)methanol
149809-43-8 Downstream products
-
310882-12-3
(2R-cis)-2-(2,4-difluorophenyl)-4-formylmethyl-2-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran
-
310882-25-8
(2R-cis)-2-(2,4-difluorophenyl)-4-(5-methyl-4-oxo-2-hexenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran
-
310882-15-6
(2R-cis)-2-(2,4-difluorophenyl)-4-(5-methyl-4-oxohexyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran
-
310882-29-2
6-[(3S,5R)-5-(2,4-Difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-yl]-2-methyl-hexan-3-one oxime