(2R,4S)-Ethyl 5-[1,1-biphenyl]-4-y)-4-amino-2-methylpentanoate hydrochloride
- CasNo:149690-12-0
Product Description
(2R,4S)-Ethyl 5-[1,1-biphenyl]-4-y)-4-amino-2-methylpentanoate hydrochloride Good Supplier In Bulk Supply High Purity 149690-12-0
- Molecular Formula: C20H26ClNO2
- Molecular Weight: 347.885
- PSA： 52.32000
- LogP: 5.31500
149690-12-0 Relevant articles
Synthesis of a Precursor to Sacubitril Using Enabling Technologies
Lau, Shing-Hing,Bourne, Samuel L.,Martin, Benjamin,Schenkel, Berthold,Penn, Gerhard,Ley, Steven V.
, p. 5436 - 5439 (2015)
An efficient preparation of a precursor ...
Preparation method of sacubitril valsartan sodium
-
Page/Page column 11-14, (2021/03/31)
The invention provides a preparation met...
AMMONIUM CARBOXYLATE COMPOUND, CRYSTALLINE FORM, AMORPHOUS FORM AND PREPARATION METHOD THEREOF
-
Paragraph 0168-0169, (2020/03/01)
The present disclosure belongs to the fi...
Purification method of sacubitril valsartan sodium intermediate
-
Paragraph 0053-0119, (2020/03/09)
The invention discloses a purification m...
Post-treatment method of sacubitril valsartan sodium intermediate
-
Paragraph 0048-0090, (2020/03/12)
The invention discloses a post-treatment...
149690-12-0 Process route
-
![(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid](/upload/2026/4/d29dc303a3954942ad1f2f53b3f991b6_39d54647-f790-4b7f-938f-c33fcbeacc95.png)
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1012341-50-2,1012341-54-6
(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
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![(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride](/upload/2026/4/c07fd175d1cf4d73b1acb9d67ad5d01e_cd023d7d-019f-4a71-948c-f60b2a2d0310.png)
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149690-12-0
(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride
| Conditions | Yield |
|---|---|
|
With
thionyl chloride;
In
ethanol;
at 60 ℃;
for 1h;
|
96.5%
|
|
With
thiophosgene;
In
ethanol;
at 70 - 75 ℃;
for 3h;
|
|
|
With
thionyl chloride;
In
ethanol; tert-butyl methyl ether;
at 60 - 70 ℃;
for 3h;
|
-
![(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one](/upload/2026/4/2a8b0c95935f4ac3aa438c926b819d40_49152b3e-e29e-4393-b7ad-7028b0dfd6a1.png)
-
1038924-70-7
(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
-
-
149690-12-0
(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride;
In
ethanol;
for 16h;
Time;
Reflux;
|
85.6%
|
|
With
hydrogenchloride;
In
methanol;
at 70 - 85 ℃;
for 24h;
|
82%
|
149690-12-0 Upstream products
-
1012341-50-2
(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
-
64-17-5
ethanol
-
1038924-66-1
(3R,5S)-5-biphenyl-4-ylmethyl-1-(2,2-dimethylpropionyl)-3-methylpyrrolidin-2-one
-
1038924-70-7
(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
149690-12-0 Downstream products
-
1038925-00-6
(3S,5S)-5-biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one
-
1038924-70-7
(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
-
1257266-04-8
(2R,4S)-5-biphenyl-4-yl-2-methyl-4-[(pyridazine-4-carbonyl)-amino]-pentanoic acid
-
1257265-93-2
6-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-butylcarbamoyl)-2-hydroxy-pyrimidine-4-carboxylic acid