5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride
- CasNo:720720-96-7
Product Description
Factory Export Top Purity 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride 720720-96-7 In Stock
- Molecular Formula: C8H11ClN2O2S
- Molecular Weight: 234.707
- Melting Point: 199.0 to 203.0 °C
- Boiling Point: 175℃[at 101 325 Pa]
- PSA： 81.67000
- LogP: 1.56910
720720-96-7 Relevant articles
Method for preparing edoxaban from trichloroacetophenone onium salt derivatives
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Paragraph 0068-0073, (2020/07/21)
The invention provides a method for prep...
Preparation method of edoxaban
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, (2019/07/08)
The invention relates to a new preparati...
METHOD FOR PRODUCING INHIBITOR OF ACTIVATED BLOOD COAGULATION FACTOR X (FXA)
-
Paragraph 0197; 0198; 0199; 0200, (2017/03/21)
An object of the present invention is to...
TRIAMINE DERIVATIVE
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Page/Page column 59, (2008/06/13)
An object of the present invention is to...
720720-96-7 Process route
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![2-bromo-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine p-toluenesulfonate](/upload/2026/4/d516d0c0e4a248a3ac3a80fa291feb08_26307af3-be9d-4434-85a0-34c4fc5152bc.png)
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852291-42-0
2-bromo-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine p-toluenesulfonate
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-
1864-94-4
phenyl formate
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![5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloric acid salt](/upload/2026/4/0d3bc1e9ff154bc18cb6dd914d4f618d_21c7ff17-1d61-4ecb-b16d-c30af00a379a.png)
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720720-96-7
5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloric acid salt
| Conditions | Yield |
|---|---|
|
2-bromo-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine p-toluenesulfonate; phenyl formate;
With
palladium diacetate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
acetonitrile;
at 60 ℃;
for 39h;
Autoclave;
Inert atmosphere;
With
lithium hydroxide monohydrate;
In
tetrahydrofuran;
at 20 ℃;
for 2h;
With
hydrogenchloride;
In
methanol;
at 20 ℃;
for 2h;
Cooling with ice;
|
86.5%
|
-
![6-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid lithium salt](/upload/2026/4/ced2c6251b3f400eacc2e42edff175be_37f9fd07-b9df-4c3a-8f1c-c6c2f56d617f.png)
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6-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid lithium salt
-
-
720720-96-7
5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloric acid salt
| Conditions | Yield |
|---|---|
|
6-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid lithium salt;
With
pyrographite;
In
ethanol;
at 40 - 50 ℃;
for 0.333333h;
With
hydrogenchloride;
In
water;
at 0 - 5 ℃;
pH=1 - Ca. 2;
|
67.8%
|
|
With
hydrogenchloride;
In
ethanol;
at 20 ℃;
for 1h;
Product distribution / selectivity;
|
|
|
With
hydrogenchloride;
In
ethanol;
at 20 ℃;
for 1h;
|
|
|
With
hydrogenchloride;
In
ethanol;
at 20 ℃;
for 1h;
|
720720-96-7 Upstream products
-
76-02-8
trifluoroacetyl chloride
-
259809-24-0
5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine
-
124-38-9
carbon dioxide
-
1445-73-4
1-Methyl-4-piperidone
720720-96-7 Downstream products
-
480449-70-5
edoxaban
-
480449-71-6
[14C]-Edoxaban tosylate
-
912273-65-5
N1 -(5-chloropyridin-2-yl)-N2 -{(1R,2R,4S)-4-(dimethylaminocarbonyl)-2-[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carboxamido]cyclohexyl}oxalamide p-toluenesulfonic acid
-
912273-65-5
N1 -(5-chloropyridin-2-yl)-N2 -{(1R,2S,4R)-4-(dimethylaminocarbonyl)-2-[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carboxamido]cyclohexyl}oxalamide p-toluenesulfonic acid