3-(4-Phenoxy-phenyl)-1-piperidin-3-y-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine
- CasNo:1022150-12-4
Product Description
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1.What is the 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine ?
(R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine is an intermediate used to prepare pyrazolo-pyrimidine compounds as inhibitors of Bruton''s tyrosine kinase. It is also an intermediate for Ibrutinib (I124970) derivatives.
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![(R)-1-(1-benzylpiperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine](/upload/2026/4/50eeff7311d848d3b441df64c957ea38_a4a81bc8-2fcd-42ee-b241-d80fb870f5b4.png)
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(R)-1-(1-benzylpiperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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![(R)-3-(4-phenoxyphenyl)-1-(piperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidine-4-amine](/upload/2026/4/ca8d1aac540d485281d9c0f95e9b1ecf_73141554-28fa-40dc-9a92-5e4c12759022.png)
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1022150-12-4
(R)-3-(4-phenoxyphenyl)-1-(piperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidine-4-amine
| Conditions | Yield |
|---|---|
|
With
hydrogen;
In
methanol; water;
at 50 ℃;
for 2h;
under 1034.32 Torr;
Acidic conditions;
|
67.4%
|
|
With
hydrogenchloride; 10 wt% Pd(OH)2 on carbon;
In
methanol;
at 40 - 50 ℃;
|
|
|
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
|
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![3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine](/upload/2026/4/55474250b20240918ab1226bc1fc6cf6_ec08bbd8-103c-4b2d-90e1-20e6f93daa47.png)
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330786-24-8
3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
-
-
143900-44-1
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
-
-
1022150-12-4
(R)-3-(4-phenoxyphenyl)-1-(piperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidine-4-amine
| Conditions | Yield |
|---|---|
|
With
di-isopropyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran;
at 25 ℃;
Temperature;
Inert atmosphere;
Large scale;
|
85%
|
|
With
di-isopropyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran;
at 0 - 30 ℃;
for 25h;
Concentration;
Temperature;
|
80.45%
|
|
3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate;
With
di-isopropyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran;
at 20 ℃;
for 5h;
With
hydrogenchloride;
In
tetrahydrofuran; water;
at 20 ℃;
for 5h;
|
69%
|
|
With
di-isopropyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran;
at 20 ℃;
for 24h;
|
52%
|
|
3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate;
With
di-isopropyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran;
at 25 ℃;
for 5.5h;
With
hydrogenchloride;
at 15 ℃;
for 2.5h;
|
45%
|
|
Multi-step reaction
with
2
steps
1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 0 - 50 °C
1.2: 20 h / 50 °C
2.1: hydrogenchloride / tetrahydrofuran; water / 2 h / 50 °C
With
hydrogenchloride; di-isopropyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran; water;
|
2.What is the CAS number for 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine ?
The CAS number of 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine is 1022150-12-4.
More information of 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine 1022150-12-4 are:
|
CAS?Number |
1022150-12-4 |
|
Density |
1.39±0.1 g/cm3(Predicted) |
|
Boiling Point |
626.3±55.0 °C(Predicted) |
|
PSA |
90.88000 |
|
LogP |
4.70230 |
|
Pka |
9.00±0.10(Predicted) |
3.What are another words for 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine ?
Synonyms?for?3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine 1022150-12-4:3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine;(R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine;3-(4-Phenoxy-phenyl)-1-(R)-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine;Btk inhibitor 1 (R enantioMer);ibrutinib N-1;3-(4-phenoxyphenyl)-1-(3-piperidyl)pyrazolo[3,4-d]pyriMidin-4-aMine;Ibrutinib intermeidate N-1;3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
4.What is the molecular formula of 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine?
The chemical formula of ?3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine is?C22H22N6O which containing 22 Carbon atoms,22 Hydrogen atoms,6 Nitrogen atoms and 1 Oxygen atoms,and the molecular weight of??3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine?is 386.456.
5.What is 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine (1022150-12-4) used for?
IBT6A is a Btk kinase inhibitor. 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine is a precurser for the manufacture of ibrutinib.
InChI:InChI=1S/C22H22N6O/c23-21-19-20(15-8-10-18(11-9-15)29-17-6-2-1-3-7-17)27-28(22(19)26-14-25-21)16-5-4-12-24-13-16/h1-3,6-11,14,16,24H,4-5,12-13H2,(H2,23,25,26)
Relevant articles related to 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine:
|
Article |
Source |
|
Preparation method of ibrutinib intermediate |
- Paragraph 0097-0099, (2021/08/06) |
|
Preparation method of precursor of ibrutinib |
- , (2020/04/22) |
6.Buy 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine with the best price .
Hangzhou World-wide Biology Tech Co.ltd is a quality supplier of 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine 1022150-12-4.