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3-Amino-5-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile

  • CasNo:330792-70-6

Product Description

Quality manufacturer supply 3-Amino-5-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile 330792-70-6 in stock with high standard

  • Molecular Formula: C16H12N4O
  • Molecular Weight: 276.297
  • Boiling Point: 585.3±50.0 °C(Predicted) 
  • PKA: 10.83±0.50(Predicted) 
  • PSA: 88.45000 
  • Density: 1.37±0.1 g/cm3(Predicted) 
  • LogP: 3.25298 

330792-70-6 Relevant articles

Regioselective Synthesis of Highly Functionalized Pyrazoles from N-Tosylhydrazones

Zhang, Qian,Tang, Meng

supporting information, (2019/03/19)

A regioselective synthesis of highly fun...

Therapeutic Combinations of a Proteasome Inhibitor and a BTK Inhibitor

-

, (2019/07/23)

Therapeutic combinations of a proteasome...

TREATMENT OF INDOLENT OR AGGRESSIVE B-CELL LYMPHOMAS USING A COMBINATION COMPRISING BTK INHIBITORS

-

, (2019/06/17)

Disclosed herein is a method for the pre...

A according to lu tini and its key intermediate for the preparation of the new method (by machine translation)

-

, (2018/03/26)

The invention relates to a according to ...

330792-70-6 Process route

4-phenoxybenzoyl chloride
1623-95-6

4-phenoxybenzoyl chloride

malononitrile
109-77-3

malononitrile

5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile
330792-70-6

5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile

Conditions
Conditions Yield
4-phenoxybenzoyl chloride; malononitrile; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 1.5h; Inert atmosphere; Cooling with ice;
With dimethyl sulfate; In tetrahydrofuran; mineral oil; for 2h; Reflux;
With triethylamine; hydrazine; In tetrahydrofuran; mineral oil; at 20 ℃; for 2h; Reflux;
18%
2-[amino(4-phenoxyphenyl)methylene]malononitrile
1055710-57-0

2-[amino(4-phenoxyphenyl)methylene]malononitrile

5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile
330792-70-6

5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile

Conditions
Conditions Yield
With hydrazine hydrate; In methanol; for 1h; Reflux;
64%

330792-70-6 Upstream products

  • 330792-69-3
    330792-69-3

    2-[(4-phenoxy-phenyl)-methoxy-methylene]-malononitrile

  • 1623-95-6
    1623-95-6

    4-phenoxybenzoyl chloride

  • 109-77-3
    109-77-3

    malononitrile

  • 21218-94-0
    21218-94-0

    methyl 4-phenoxybenzoate

330792-70-6 Downstream products

  • 928309-79-9
    928309-79-9

    C24 H19 BrN4 O

  • 1207957-96-7
    1207957-96-7

    C25 H21 BrN4 O

  • 928309-83-5
    928309-83-5

    C25 H21 BrN4 O2

  • 928309-86-8
    928309-86-8

    C25 H21 BrN4 O2

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