5-Bromoacetyl-2-bensyloxybenzoic acid methyl ester
- CasNo:27475-14-5
Product Description
Factory Sells Best Quality 5-Bromoacetyl-2-bensyloxybenzoic acid methyl ester 27475-14-5 with GMP standards
- Molecular Formula: C17H15BrO4
- Molecular Weight: 363.208
- Vapor Pressure: 3.38E-10mmHg at 25°C
- Boiling Point: 501.7oC at 760 mmHg
- Flash Point: 257.2oC
- PSA： 52.60000
- Density: 1.414g/cm3
- LogP: 3.62980
5-BROMOACETYL-2-BENSYLOXYBENZOIC ACID METHYL ESTER(Cas 27475-14-5) Usage
|
General Description |
5-Bromoacetyl-2-bensyloxybenzoic acid methyl ester is a chemical compound with potential applications in organic synthesis and medicinal chemistry. It is a derivative of benzoic acid and contains a bromine atom, acetyl group, and a methyl ester functionality. 5-BROMOACETYL-2-BENSYLOXYBENZOIC ACID METHYL ESTER may be used as a building block for the synthesis of other organic molecules, or as a precursor for the preparation of pharmaceutical compounds. The presence of functional groups such as acetyl and methyl ester make it a versatile starting material for the development of biologically active molecules. Its specific applications and potential uses in research and industry would depend on its reactivity and the availability of suitable synthetic pathways. |
InChI:InChI=1/C17H15BrO4/c1-21-17(20)14-9-13(15(19)10-18)7-8-16(14)22-11-12-5-3-2-4-6-12/h2-9H,10-11H2,1H3
27475-14-5 Relevant articles
Conformational control enabled by the fluorine gauche effect in a model of the β2-AR agonist salbutamol (Ventolin)
Teschers, Charlotte S.,Daniliuc, Constantin G.,Kehr, Gerald,Gilmour, Ryan
supporting information, p. 1 - 5 (2018/03/13)
The bronchodilator salbutamol adopts a c...
PROCESS FOR THE PREPARATION OF SALMETEROL AND ITS INTERMEDIATES
-
Page/Page column 25-26, (2012/03/27)
The present invention discloses a proces...
A multivalent approach to the discovery of long-acting β2- adrenoceptor agonists for the treatment of asthma and COPD
Jacobsen, John R.,Choi, Seok Ki,Combs, Jesse,Fournier, Eric J.L.,Klein, Uwe,Pfeiffer, Juergen W.,Thomas, G. Roger,Yu, Cecile,Moran, Edmund J.
scheme or table, p. 1213 - 1218 (2012/03/11)
A multivalent approach was applied to th...
PHENYL SUBSTITUTED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS POSSESSING BETA AGONIST ACTIVITY
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Page/Page column 52; 84, (2008/06/13)
The present invention relates to sodium ...
27475-14-5 Process route
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27475-09-8
5-acetyl-2-benzyloxybenzoic acid methyl ester
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27475-14-5
2-benzyloxy-5-(2-bromoacetyl)benzoic acid methyl ester
| Conditions | Yield |
|---|---|
|
With
bromine;
In
chloroform;
at 0 - 20 ℃;
Inert atmosphere;
|
97%
|
|
With
N-Bromosuccinimide; sulfuric acid;
In
acetonitrile;
at 50 ℃;
for 1h;
|
81%
|
|
With
aluminium trichloride; bromine;
In
diethyl ether;
for 3h;
Ambient temperature;
|
78%
|
|
With
phenyltrimethylammonium tribromide;
In
tetrahydrofuran;
for 18h;
|
72%
|
|
With
bromine;
In
chloroform;
for 3h;
|
70%
|
|
With
bromine;
In
chloroform;
for 2.5h;
|
55%
|
|
With
bromine;
In
chloroform;
for 3h;
|
55%
|
|
With
bromine;
|
|
|
With
bromine;
In
chloroform;
|
-
-
16475-90-4
estere metilico dell'acido 5-acetilsalicilico
-
-
27475-14-5
2-benzyloxy-5-(2-bromoacetyl)benzoic acid methyl ester
| Conditions | Yield |
|---|---|
|
Multi-step reaction
with
2
steps
1: 55 percent / Na / ethanol / 30 h / Heating
2: 78 percent / AlCl3
, bromine / diethyl ether / 3 h / Ambient temperature
With
aluminium trichloride; bromine; sodium;
In
diethyl ether; ethanol;
|
|
|
Multi-step reaction
with
2
steps
1: K2
CO3
2: Br2
With
bromine; potassium carbonate;
|
|
|
Multi-step reaction
with
2
steps
1: potassium carbonate / acetonitrile
2: bromine / chloroform
With
bromine; potassium carbonate;
In
chloroform; acetonitrile;
|
|
|
Multi-step reaction
with
2
steps
1: potassium carbonate / potassium iodide / N,N-dimethyl-formamide / 2 h / 50 - 65 °C
2: N-Bromosuccinimide; sulfuric acid / acetonitrile / 1 h / 50 °C
With
N-Bromosuccinimide; sulfuric acid; potassium carbonate;
potassium iodide;
In
N,N-dimethyl-formamide; acetonitrile;
|
|
|
Multi-step reaction
with
2
steps
1: potassium carbonate / acetonitrile / 16 h / 75 °C
2: bromine / chloroform / 0 - 20 °C / Inert atmosphere
With
bromine; potassium carbonate;
In
chloroform; acetonitrile;
|
|
|
Multi-step reaction
with
2
steps
1: sodium carbonate; sodium iodide / acetonitrile / 16 h / Heating / reflux
2: phenyltrimethylammonium tribromide / tetrahydrofuran / 18 h
With
phenyltrimethylammonium tribromide; sodium carbonate; sodium iodide;
In
tetrahydrofuran; acetonitrile;
|
27475-14-5 Upstream products
-
27475-09-8
5-acetyl-2-benzyloxybenzoic acid methyl ester
-
16475-90-4
estere metilico dell'acido 5-acetilsalicilico
-
100-44-7
benzyl chloride
-
7789-45-9
copper(II)bromide
27475-14-5 Downstream products
-
74068-80-7
5-(2-{Benzyl-[1-(4-cyclohexyl-phenyl)-ethyl]-amino}-acetyl)-2-benzyloxy-benzoic acid methyl ester
-
160889-18-9
2-benzyloxy-5-(2-bromo-1(R)-hydroxyethyl)benzoic acid methyl ester
-
744137-94-8
5-(N-Benzyl-N-isopropylglycyl)-2-benzyloxy-benzoesaeure-methylester
-
35459-07-5
methyl 5-(2-(benzyl(tert-butyl)amino)-1-hydroxyethyl)-2-(benzyloxy)benzoate